•90% of diabetes cases,
•80% of coronary diseases,
•70% of cardiovascular mortality,
•50% of cancer mortality and
•40% of dementia cases
can be attributed to an unhealthy lifestyle. A balanced diet, regular physical activity integrated into daily life, and a strong sense of community contribute to health and well-being.
The 4Habits platform uses artificial intelligence, big data, and advanced algorithms based on the latest peer reviewed articles to periodically check risk factors for frailty and turn a healthy lifestyle into a habit.
Science behind
We base our technology on the latest research
Healthy lifestyle and prevention
Livingston, G., Huntley, J., Sommerlad, A., Ames, D., Ballard, C., Banerjee, S., Brayne, C., Burns, A., Cohen-Mansfield, J., Cooper, C., Costafreda, S. G., Dias, A., Fox, N., Gitlin, L. N., Howard, R., Kales, H. C., Kivimäki, M., Larson, E. B., Ogunniyi, A., & Orgeta, V. (2020). Dementia prevention, intervention, and care: 2020 report of the lancet commission. The Lancet, 396(10248), 413–446.
World Health Organization. (2018). Noncommunicable Diseases Country Profiles 2018 [Review of Noncommunicable Diseases Country Profiles 2018]. The American University in Cairo; World Health Organization.
Physical activity
Warburton, D. E. R., & Bredin, S. S. D. (2017). Health Benefits of Physical activity: a Systematic Review of Current Systematic Reviews. Current Opinion in Cardiology, 32(5), 541–556.
Rebar, A. L., Dimmock, J. A., Jackson, B., Rhodes, R. E., Kates, A., Starling, J., & Vandelanotte, C. (2016). A systematic review of the effects of non-conscious regulatory processes in physical activity. Health Psychology Review, 10(4), 395–407.
Hötting, K., & Röder, B. (2013). Beneficial effects of physical exercise on neuroplasticity and cognition. Neuroscience and Biobehavioral Reviews, 37(9 Pt B), 2243–2257.
Nutrition
Gómez-Gómez, M. E., & Zapico, S. C. (2019). Frailty, Cognitive Decline, Neurodegenerative Diseases and Nutrition Interventions. International Journal of Molecular Sciences, 20(11), 2842.
Yassine, H. N., Samieri, C., Livingston, G., Glass, K., Wagner, M., Tangney, C., Plassman, B. L., Ikram, M. A., Voigt, R. M., Gu, Y., O’Bryant, S., Minihane, A. M., Craft, S., Fink, H. A., Judd, S., Andrieu, S., Bowman, G. L., Richard, E., Albensi, B., & Meyers, E. (2022). Nutrition state of science and dementia prevention: recommendations of the Nutrition for Dementia Prevention Working Group. The Lancet Healthy Longevity, 3(7), e501–e512.
Hu, F. B. (2023). Diet strategies for promoting healthy aging and longevity: An epidemiological perspective. Journal of Internal Medicine.
Thapsuwan, S., Phulkerd, S., Chamratrithirong, A., Gray, R. S., Jindarattanaporn, N., Loyfah, N., Thongcharoenchupong, N., & Pattaravanich, U. (2024). Relationship between consumption of high fat, sugar or sodium (HFSS) food and obesity and non-communicable diseases. BMJ Nutrition, Prevention & Health, e000794.
Paweł Smuszkiewicz-Różański, Różańska-Smuszkiewicz, G., Karolina Koszyczarek, Maja Kotowska, Wiktoria Zamirska, Albin Ziemiański, Katarzyna Zięba, & Zygmunt, A. (2024). How does the consumption of processed food affect the pathogenesis of various diseases? - literature review. Journal of Education, Health and Sport, 61, 109–128.
Watling, C. Z., Wojt, A., Florio, A. A., Butera, G., Albanes, D., Weinstein, S. J., Huang, W.-Y., Parisi, D., Zhang, X., Graubard, B. I., Petrick, J. L., & McGlynn, K. A. (2024). Fiber and whole grain intakes in relation to liver cancer risk: An analysis in two prospective cohorts and systematic review and meta-analysis of prospective studies. Hepatology.
Soleymani, S., Habtemariam, S., Rahimi, R., & Nabavi, S. M. (2020). The what and who of dietary lignans in human health: Special focus on prooxidant and antioxidant effects. Trends in Food Science & Technology, 106, 382–390.
Sakkas, H., Bozidis, P., Touzios, C., Kolios, D., Athanasiou, G., Athanasopoulou, E., Gerou, I., & Gartzonika, C. (2020). Nutritional Status and the Influence of the Vegan Diet on the Gut Microbiota and Human Health. Medicina, 56(2).
Brain health
Harada, C. N., Natelson Love, M. C., & Triebel, K. L. (2013). Normal Cognitive Aging. Clinics in Geriatric Medicine, 29(4), 737–752.
Kwakowsky, A., Milne, M., Waldvogel, H., & Faull, R. (2016). Effect of Estradiol on Neurotrophin Receptors in Basal Forebrain Cholinergic Neurons: Relevance for Alzheimer’s Disease. International Journal of Molecular Sciences, 17(12), 2122.
Govindpani, K., Calvo Flores, B., Vinnakota, C.,Waldvogel, H. J., Faull, R.L., Kwakowsky, A. (2017). Towards a Better Understanding of GABAergic Remodeling in Alzheimer’s Disease. International Journal of Molecular Sciences, 18(8), 1813.
Palpagama, T. H., Waldvogel, H. J., Faull, R. L. M., & Kwakowsky, A. (2019). The Role of Microglia and Astrocytes in Huntington’s Disease. Frontiers in Molecular Neuroscience, 12.
Palpagama, T. H., Mills, A., Mackenzie Wendy Ferguson, Praju Vikas Ankeal, Turner, C., Tippett, L. J., Bert, Waldvogel, H. J., Richard, & Kwakowsky, A. (2023). Microglial and Astrocytic Responses in the Human Midcingulate Cortex in Huntington’s Disease. Annals of Neurology, 94(5), 895–910.
Calvo-Flores Guzmán, B., Elizabeth Chaffey, T., Hansika Palpagama, T., Waters, S., Boix, J., Tate, W. P., Peppercorn, K., Dragunow, M., Waldvogel, H. J., Faull, R. L. M., & Kwakowsky, A. (2020). The Interplay Between Beta-Amyloid 1-42 (Aβ1-42)-Induced Hippocampal Inflammatory Response, p-tau, Vascular Pathology, and Their Synergistic Contributions to Neuronal Death and Behavioral Deficits. Frontiers in Molecular Neuroscience, 13, 522073.
Rao, R., & Topiwala, A. (2020). Alcohol use disorders and the brain. Addiction, 115(8).
Sushma, Divakar, A., Kanchan, S., Jha, G., Mishra, S., Sharma, D., & Rath, S. K. (2021). Alcohol induced impairment/abnormalities in brain: Role of MicroRNAs. NeuroToxicology, 87, 11–23.
Zhang, Z., Luh, W.-M., Duan, W., Zhou, G. D., Weinschenk, G., Anderson, A. K., & Dai, W. (2021). Longitudinal effects of meditation on brain resting-state functional connectivity. Scientific Reports, 11(1).
Sharp, P. B., Sutton, B. P., Paul, E. J., Sherepa, N., Hillman, C. H., Cohen, N. J., Kramer, A. F., Prakash, R. S., Heller, W., Telzer, E. H., & Barbey, A. K. (2018). Mindfulness training induces structural connectome changes in insula networks. Scientific Reports, 8(1), 1–10.
Hasenkamp, W., & Barsalou, L. W. (2012). Effects of meditation experience on functional connectivity of distributed brain networks. Frontiers in Human Neuroscience, 6, 38.
Lit, R. (2023, March 13). What Happens When You Meditate. Stanford Magazine. https://stanfordmag.org/contents/what-happens-when-you-meditate
Shuda, Q., Bougoulias, M. E., & Kass, R. (2020). Effect of nature exposure on perceived and physiologic stress: A systematic review. Complementary Therapies in Medicine, 53, 102514.
Li, D., Menotti, T., Ding, Y., & Wells, N. M. (2021). Life Course Nature Exposure and Mental Health Outcomes: A Systematic Review and Future Directions. International Journal of Environmental Research and Public Health, 18(10), 5146.
Pal GK, Velkumary S, Madanmohan. Effect of short-term practice of breathing exercises on autonomic functions in normal human volunteers. Indian J Med Res. 2004 Aug;120(2):115-21. PMID: 15347862.
Wang, J., Wei, Z., Yao, N., Li, C., & Sun, L. (2023). Association Between Sunlight Exposure and Mental Health: Evidence from a Special Population Without Sunlight in Work. Association between Sunlight Exposure and Mental Health: Evidence from a Special Population without Sunlight in Work, Volume 16, 1049–1057.
Mead, M. N. (2008). Benefits of Sunlight: A Bright Spot for Human Health. Environmental Health Perspectives, 116(4).
Urwyler, P., Gupta, R. K., Falkner, M., Niklaus, J., Müri, R. M., & Nef, T. (2023). Tablet-Based Puzzle Game Intervention for Cognitive Function and Well-Being in Healthy Adults: Pilot Feasibility Randomized Controlled Trial. JMIR Aging, 6(1), e46177.
Yahya, Q. N. Q., Purwaningsih, P., & Makhfudli, M. (2019). Influence of Cognitive Stimulation Group Activity Memory Game Therapy on Elderly Cognitive Function: Quasi-Experimental. Jurnal Ners, 14(3si), 242-246
Recovery
Godos, J., Ferri, R., Lanza, G., Caraci, F., Vistorte, A. O. R., Yelamos Torres, V., Grosso, G., & Castellano, S. (2024). Mediterranean Diet and Sleep Features: A Systematic Review of Current Evidence. Nutrients, 16(2), 282.
Ma, M., Fan, Y., Peng, Y., Ma, Q., Jia, M., Qi, Z., Yang, J., Wang, W., Ma, X., & Yan, B. (2024). Association of sleep timing with all-cause and cardiovascular mortality: the Sleep Heart Health Study and the Osteoporotic Fractures in Men Study. Journal of Clinical Sleep Medicine, 20(4), 545–553.
Taheri, S. (2024). Waking up to sleep extension for cardiometabolic health. Sleep.
Franken, P., & Dijk, D.-J. (2023). Sleep and circadian rhythmicity as entangled processes serving homeostasis. Nature Reviews Neuroscience, 1–17.
Wang, R., Xinyi Lv, Xu, W., Li, X., Tang, X., Huang, H., Yang, M., Ma, S., Wang, N., & Niu, Y. (2024). Effects of the periodic fasting-mimicking diet on health, lifespan, and multiple diseases: a narrative review and clinical implications. Nutrition Reviews.
Golbidi, S., Daiber, A., Korac, B., Li, H., Essop, M. F., & Laher, I. (2017). Health Benefits of Fasting and Caloric Restriction. Current Diabetes Reports, 17(12), 123.
Cramer, S. C., Sur, M., Dobkin, B. H., O’Brien, C., Sanger, T. D., Trojanowski, J. Q., Rumsey, J. M., Hicks, R., Cameron, J., Chen, D., Chen, W. G., Cohen, L. G., deCharms, C., Duffy, C. J., Eden, G. F., Fetz, E. E., Filart, R., Freund, M., Grant, S. J., & Haber, S. (2011). Harnessing neuroplasticity for clinical applications. Brain, 134(6), 1591–1609.
Laukkanen, J. A., Laukkanen, T., & Kunutsor, S. K. (2018). Cardiovascular and Other Health Benefits of Sauna Bathing: A Review of the Evidence. Mayo Clinic Proceedings, 93(8), 1111–1121.
Heinonen, I., & Laukkanen, J. A. (2018). Effects of heat and cold on health, with special reference to Finnish sauna bathing. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 314(5), R629–R638.
Scott, M. C., & Fuller, S. (2023). The Effects of Intermittent Cold Exposure on Adipose Tissue. International Journal of Molecular Sciences, 25(1), 46–46.
AI
Gu, J., Gao, C., & Wang, L. (2023). The Evolution of Artificial Intelligence in Biomedicine: Bibliometric Analysis. JMIR AI, 2(1), e45770.
Armand, T., Opeyemi Deji-Oloruntoba, Bhattacharjee, S., Kintoh Allen Nfor, & Kim, H.-C. (2024). Optimizing longevity: Integrating Smart Nutrition and Digital Technologies for Personalized Anti-aging Healthcare. 2024 International Conference on Artificial Intelligence in Information and Communication (ICAIIC).
Yazdi, M., Zarei, E., Adumene, S., & Beheshti, A. (2024). Navigating the Power of Artificial Intelligence in Risk Management: A Comparative Analysis. Safety, 10(2), 42.
Habits formation
Gardner, B., Lally, P., & Wardle, J. (2012). Making health habitual: the psychology of “habit-formation” and general practice. British Journal of General Practice, 62(605), 664–666.
Lally, P., & Gardner, B. (2013). Promoting habit formation. Health Psychology Review, 7(sup1), S137–S158.
Gardner, B. (2014). A review and analysis of the use of “habit” in understanding, predicting and influencing health-related behaviour. Health Psychology Review, 9(3), 277–295.
Gardner, B., & Lally, P. (2018). Modelling Habit Formation and Its Determinants. The Psychology of Habit, 207–229.
Productivity
Kirsten, W. (2010). Making the link between health and productivity at the workplace ―A global perspective. Industrial Health, 48(3), 251–255.